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Endocrine Abstracts

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ea0008oc2 | Growth and Development | SFE2004

Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies

Aldibbiat A , Scougall KT , Campbell SC , Macfarlane WM , Shaw JAM

Transdifferentiation of non-endocrine pancreatic cells towards a beta-cell phenotype may enable insulin independence in many individuals from a single donor. This will be dependent on near-physiological proinsulin biosynthesis, processing, storage and secretion. The aim of this study was to fully characterise endocrine potential of pancreatic acinar cells before and after transdifferentiation.Expression of exocrine/endocrine markers in the AR42J rat acin...
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ea0008dp18 | Diabetes, metabolism and cardiovascular | SFE2004

Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies

Aldibbiat A , Scougall KT , Campbell SC , Macfarlane WM , Shaw JAM

Transdifferentiation of non-endocrine pancreatic cells towards a beta-cell phenotype may enable insulin independence in many individuals from a single donor. This will be dependent on near-physiological proinsulin biosynthesis, processing, storage and secretion. The aim of this study was to fully characterise endocrine potential of pancreatic acinar cells before and after transdifferentiation.Expression of exocrine/endocrine markers in the AR42J rat acin...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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